Khảo sát độc tính cấp và tác động chống đông máu của huyết giác (Dracaena cambodiana Pierre ex Gagnep.,Dracaenaceae)

Abstract

Oral acute toxicity and antithrombotic effect of the ethanol extracts from Dracaena cambodiana Pierre ex. Gagnep (DC extract) were estimated in mice with pulmonary thrombosis induced by 600 mg/kg collagen and 0.5 mg/kg epinephrine. The extracts showed no acute toxicity in mice at the oral dose of 2 g/kg BW (equivalent to 15.92 g dry plant material/kg BW). At the dose of 100 mg/kg and 200 mg/kg, the extracts resulted in a significant increase in bleeding time and clearly protected mice from such experimental pulmonary embolism after an oral administration course of 7 successive days. The dose of 100 mg/kg proved the same antithrombotic effect as did 5 mg/kg aspirin. And noteworthy, less powerful was the higher dose of 200 mg/kg. These suggested the use of DC extracts for thrombosis prevention and treatment.