Nghiên cứu khả năng kháng oxy hóa và ức chế enzym &-glucosidase của cao chiết từ lá cây lá đắng (Vernonia amygdalina Del.), họ Cúc (Asteraceae)

Abstract

The plant Vernonia amygdalina Del. (Asteraceae) (“lá đắng" - bitter leaf plant) was studied for antioxidant activity and inhlbltive power on a-glucosidase enzyme. The dlchloromethane extracts showed the best in bioactivities in question. The extraction was investigated for high efficiency and potential Inhibitivity on a-glucosidase enzyme. Finally the extration was optimized as: the plant powders were extracted three times, once with ethanol 40% (v/v) solid-to-liquid ratio of 1/5 (w/v) at 50°C for 40 min. The obtained extracts showed antioxidant activity (IC₅₀ = 51.9 µg/mL) and good inhibitivity on a-glucosidase enzyme (IC₅₀ = 480 pg/mL), much higher than the ethanol and aqueous extracts.