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https://dspace.ctu.edu.vn/jspui/handle/123456789/54564
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DC Field | Value | Language |
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dc.contributor.author | Tạ, Mạnh Hùng | - |
dc.contributor.author | Phạm, Thanh Huyền | - |
dc.contributor.author | Phan, Thị Nghĩa | - |
dc.date.accessioned | 2021-06-08T08:42:05Z | - |
dc.date.available | 2021-06-08T08:42:05Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0866-7861 | - |
dc.identifier.uri | https://dspace.ctu.edu.vn/jspui/handle/123456789/54564 | - |
dc.description.abstract | An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed for determination of domperidone in human plasma with diphenhydramine as internal standard: Column - C18 (150 x 4.6mm, i.d., 5 pm); mobile phase - 0.05% formic acid - methanol - acetonitrile - isopropanol (suitable ratio): flow rate - 0,5 ml/min (isocratic elution). The UPLC-MS/MS was operated in the multi reaction-monitoring mode using the electrospray ionization technique. For injection samples, domperidone and the internal standard (diphenhydramine) were extracted from human plasma by liquid-liquid extraction with a mixture of diethylether and chloroform. Good linearity for standard curves was found at the range of 0.5 to 50 ng/mi for domperidone (mean correlation coefficient R² ≥ 0.99). The intra-day and inter-day precision and accuracy were within 88.8% - 106.8%. The method was excellently time-saving - the total run time was 4 min only. This method showed applicable to BA-BE studies of domperidone preparations. | vi_VN |
dc.language.iso | vi | vi_VN |
dc.relation.ispartofseries | Tạp chí Dược học;Số 507 .- Tr.29-34 | - |
dc.subject | Domperidone | vi_VN |
dc.subject | Determination | vi_VN |
dc.subject | Human plasma | vi_VN |
dc.subject | UPLC-MS/MS | vi_VN |
dc.title | Định lượng domperidon trong huyết tương người bằng phương pháp sắc ký lỏng siêu hiệu năng ghép nối vói detector khối phổ (UPLC-MS/MS) | vi_VN |
dc.type | Article | vi_VN |
Appears in Collections: | Dược học |
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_file_ Restricted Access | 3.73 MB | Adobe PDF | ||
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