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https://dspace.ctu.edu.vn/jspui/handle/123456789/54566
Title: | Xây dựng phương pháp định lượng fenoflbrat và acid fenofibric trong huyết tương chó bằng sắc ký lỏng hiệu năng cao |
Authors: | Nguyễn, Thị Thuận Nguyễn, Ngọc Chiến Phạm, Thị Huyền Chang Nguyễn, Thị Ngọc Lê, Đình Hùng |
Keywords: | Fenofibrat Acid fenofibnc Determination HPLC Serum |
Issue Date: | 2018 |
Series/Report no.: | Tạp chí Dược học;Số 507 .- Tr.41-44 |
Abstract: | An HPLC method for simultaneous determination of serum fenofibrate (FB) and fenofibric acid (FA) as their serum active metabolites with sodium diclofenac as internal standard was developed: Column - Shim-pack GIST C18 (150x 4.60 mm; 5 pm): Mobile phase - mixture of MeOH and phosphate buffer pH 3.0; detector UV: 286 nm. The LODs were 0.2 pg/mL plasma for both FB and FA. Validated according to the guidelines for validation of bioanalytical methods of FDA and EMA. These all proved the proposed method reliable and practicable. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/54566 |
ISSN: | 0866-7861 |
Appears in Collections: | Dược học |
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File | Description | Size | Format | |
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_file_ Restricted Access | 2.68 MB | Adobe PDF | ||
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