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https://dspace.ctu.edu.vn/jspui/handle/123456789/54578
Title: | Nghiên cứu bào chế phytosome chứa polyphenol chiết xuất từ lá chè xanh (Camellia sinensis L.) |
Authors: | Nguyễn, Trọng Điệp Nguyễn, Hoàng Hiệp Nguyễn, Thị Thanh Hằng Trần, Kim Thanh Vũ, Bình Dương |
Keywords: | Green tea Polyphenol Phytosome |
Issue Date: | 2018 |
Series/Report no.: | Tạp chí Dược học;Số 508 .- Tr.10-15 |
Abstract: | A technical procedure was developed for preparation of phytosome dosage forms of the leaf polyphenols of the Vietnamese green tea (Camellia sinensis L.) with phosphatidylcholine (PC). The PP-PC complex forming reaction was optimized as follows: The reaction solvent - ethanol at 60%; the ratio of PP/PC -14; reaction temperature - 40°C; reaction time - 2 hrs. The obtained solutions were spray-dried to get phytosome products (PHY) in form of light yellow powder with the particle size of about a few micrometers; the total content of PP was 271.02 ± 13.92 mg/g, the content of PP in the complex 251.60 ± 12.91 mg/g, and the drug entrapment percentage 85.69 ± 4.40%. The complexity between PP and PC was demonstrated by DSC, FTIR, X-ray diffraction. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/54578 |
ISSN: | 0866-7861 |
Appears in Collections: | Dược học |
Files in This Item:
File | Description | Size | Format | |
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_file_ Restricted Access | 3.9 MB | Adobe PDF | ||
Your IP: 18.119.117.122 |
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