Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/54579
Title: Nghiên cứu xây dựng công thức viên nén dạng cốt lornoxicam giải phóng kéo dài với tá dược hydroxypropyl methylcellulose
Authors: Đồng, Thị Hoàng Yến
Vũ, Đình Tuấn
Phạm, Thành Đạt
Nguyễn, Thạch Tùng
Nguyễn, Đăng Hòa
Keywords: Lornoxlcam
Sustained-release
Matrix tablets
Hydroxypropyl methylcellulose
Issue Date: 2018
Series/Report no.: Tạp chí Dược học;Số 508 .- Tr.15-20
Abstract: Taking lornoxicam as a potent non-steroidal anti-inflammatory drug with a short half-time (3-4 hours), sustained-release tablets of lornoxicam 8 mg were formulated with hydroxypropyl methylcellulose as hydrophilic matrix by wet granulation. The combination of Methocel K4M and Methocel E15 were proven as the optimum carriers for the tablets. The drug release of lornoxicam from the obtained sustained release tablets well followed the zero-order release model after 8 hours in the medium of phosphate buffer saline pH 6.8.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/54579
ISSN: 0866-7861
Appears in Collections:Dược học

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