Nghiên cứu xây dựng công thức viên nén dạng cốt lornoxicam giải phóng kéo dài với tá dược hydroxypropyl methylcellulose

Abstract

Taking lornoxicam as a potent non-steroidal anti-inflammatory drug with a short half-time (3-4 hours), sustained-release tablets of lornoxicam 8 mg were formulated with hydroxypropyl methylcellulose as hydrophilic matrix by wet granulation. The combination of Methocel K4M and Methocel E15 were proven as the optimum carriers for the tablets. The drug release of lornoxicam from the obtained sustained release tablets well followed the zero-order release model after 8 hours in the medium of phosphate buffer saline pH 6.8.