Tổng hợp và khảo sát hoạt tính kháng nấm, kháng khuẩn của một số dẫn chất 2-acetamidobenzothiazoI

Abstract

Two N-(benzothiazole-2’-yl)-2-chloroacetamide derivatives were obtained from aniline in reaction with ammonium thiocyanate and monochloroacetyl chloride. Further, six derivatives of 2 cycloaminoacetamido-benzothiazole were synthesized by condensation with cycloamines. All of the newly synthesized compounds were characterized by melting point, thin layer chromatochraphy (TLC), structural elucidation by UV, IR, 1H-NMR, 13C-NMR and MS. By testing the antibacterial activitiy, of these synthesized derivatives, only 2 showed effective on the MRSA, C. albicans, T. mentagrophytes, T. rubrum.