Tổng hợp và thử hoạt tính kháng khuẩn, kháng nấm của các dẫn chất phenylpyridinylthiourea

Abstract

Phenylisothiocyanate was synthesized by thiocarbanilide method. The combination of phenylisothiocyanate or 3-clorophenylisothiocyanate with aminopyridins occured at room temperature in quite high yield (about 95%). In quantitative structure-activity relationship (QSAR), the synthesized products from materials with the amino group on the 3ⁿ ͩ position of the pyridine ring exhibited better antibactena! and antifungal activity than those from the materials with amino group on the 2ⁿ ͩ position of the pyridine ring.