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https://dspace.ctu.edu.vn/jspui/handle/123456789/54644
Title: | Biến cố kéo dài khoảng QTcF ở bệnh nhân sử dụng phác đồ có bedaquilin trong Chương trình Chống lao Quốc gia |
Authors: | Nguyễn, Thị Thủy Nguyễn, Bảo Ngọc Nguyễn, Thị Mai Phương Hoàng, Thị Thanh Thủy Nguyễn, Viết Nhung Nguyễn, Mai Hoa Vũ, Đình Hòa Nguyễn, Hoàng Anh Nguyễn, Quốc Thái |
Keywords: | Bedaquiline Hypokalaemia QTcF prolongation Pre-XDR-TB XDR-TB |
Issue Date: | 2018 |
Series/Report no.: | Tạp chí Dược học;Số 509 .- Tr.72-75 |
Abstract: | Characteristics and risk factors for QTcF prolongation in patients on bedaquiline (Bdq)-containing regimen by the Vietnam’s National Programme for Antituberculosis were investigated. The study involved a cohort of adult patients with pre-XDR-TB and XDR-TB using Bdq-based regimen. The adverse events were managed under cohort event-monitoring and QT prolongation was evaluated according to Fredericks corrected QT value (QTcF). 64.6% of patients suffered from QTcF prolongation including 14.1% with severe events (QTcF > 500 ms). QTcF prolonging events were most likely to occur during the first two weeks with high Bdq doses. Really, cachexia, hypomagnesemia and hypokalaemia were independent risk factors of QTcF prolongation. These findings suggested close monitoring by electrocardiography to detect cardiovascular events, especially in those patients with electrolyte disturbances. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/54644 |
ISSN: | 0866-7861 |
Appears in Collections: | Dược học |
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