Điều chế hệ tiểu phân nano chứa cao linh chi (Ganoderma lucidum (Leyss. ex Fr.) Karst.) hướng tác dụng kháng cholinestcrase

Abstract

With regard the natural triterpenoids of Lingzhi (Ganoderma lucidum (Leyss. ex Fr.) Karst.) that are known as active principles for treatment of dementia-related diseases such as Alzheimer, but of poor absorbility due their hydrophobic nature, nanodispersion dosage forms of the triterpenoid-rich extracts from the Red Lingzhi of Vietnam (NPs-L) were formulated to enhance the cellular uptake of triterpenoids. The obtained products were charaterized. The particle size averaged at ca. 143.940 ± 2.525 nm; the stability derirable for at least 6 months of storage at 30 ± 2 cC and ambient relative humidity of 75% ± 5%; the inhibitory activity on cholinesterase was demonstrated by Ellman method, reaching 50% at 0.094 pg/mL (IC₅₀ = 0.094 pg/mL), as 2.59 times higher than the initial Lingzhi extracts (IC₅₀ = 0.244 pg/mL).