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https://dspace.ctu.edu.vn/jspui/handle/123456789/54649| Title: | Tổng hợp và thử hoạt tính gây độc tế bào ung thư của một số dẫn chất acylhydrazon mang khung 4(3H)-quinazolinon |
| Authors: | Cao, Thị Cẩm Nhung Lê, Công Trực Cao, Việt Phương Trần, Phương Thảo Nguyễn, Hải Nam |
| Keywords: | 4(3H)-Quinazolinone Acylhydrazone Procaspase-3 |
| Issue Date: | 2018 |
| Series/Report no.: | Tạp chí Dược học;Số 510 .- Tr.3-7 |
| Abstract: | 5 novel procaspase-3 activating acylhydrazones synthesized incorporating 4(3H)-quinazolinones (Va-ej and biologically tested for cytotoxicity. These all 5 synthesized compounds exhibited significant cytotoxicity against the foilwing three human cancer cell lines: SW620, colon cancer; PC-3, prostate cancer; NCI-H23, lung cancer. Of them, the most potent compound Vb displayed the highest cytotoxicity, as up to 4-fold as potent than 5-FU (5-fluorouracil). |
| URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/54649 |
| ISSN: | 0866-7861 |
| Appears in Collections: | Dược học |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| _file_ Restricted Access | 3.87 MB | Adobe PDF | ||
| Your IP: 18.117.93.183 |
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