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Title: | Khảo sát hoạt tính kháng viêm in vitro của các hợp chất alkaloid từ rễ cây bá bệnh ( Elongifolia Jack) |
Authors: | Lê, Thanh Liêm Đào, Thị Thanh Hiền Phạm, Thanh Bình Phạm, Văn Cường Nguyễn, Tiến Đạt Nguyễn, Hải Đăng |
Keywords: | Eurycoma longifolia Canthin-6-one Alkaloid |
Issue Date: | 2018 |
Series/Report no.: | Tạp chí Dược học;Số 510 .- Tr.12-15 |
Abstract: | Four canthin-6-one alkaloids were isolated from the root extracts of Eurycoma longifolia (Jack). By spectroscopical elucidation, they were identified as: 9-hydroxycathin-6-one (1), 9-methoxycanthin-6-one (2), 9,10-dimethoxycanthin-6-one (3) and 5-methoxycanthin-6-one (4). Compounds (3) and (4) were isolated from the roots ofE. iongifolia growing in Vietnam for the first time. In an in vitro anti-inflammatory assay compound (3) exhibited significant inhibitory activity on the NO production in LPS-induced RAW264.7 cells. The ICX value of (3) was determined as 33.11 ± 2.98pM. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/54651 |
ISSN: | 0866-7861 |
Appears in Collections: | Dược học |
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