Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/54661
Title: Phương pháp tổng hợp exemestan từ họp chất androsta-1,4-dien-3,17-dion
Authors: Cao, Đức Tuấn
Trịnh, Thị Hải
Bạch, Thị Như Quỳnh
Nguyễn, Hồng Thu
Bùi, Thị Thắm
Trịnh, Hiền Trung
Phạm, Văn Thức
Nguyễn, Văn Hùng
Keywords: Exemestane
Steroid
Breast cancer
Androsta-1,4-dien-3,17-dione
Issue Date: 2018
Series/Report no.: Tạp chí Dược học;Số 510 .- Tr.35-38
Abstract: As regarding exemestane (1) as a 3rd-generation aromatase inhibitor widely used for treatment of hormone dependent breast cancer in postmenopausal women, it was synthesized with a 3-step method from androsta-1,4-diene-3,17-dione (2). Firstly, compound 2 was converted to 1,3-dipyrrolidinoandrosta-3,5-dien-17-on (3) and the intermediate product 3 was used immediately in the second step to afford 6-(hydroxymethyl)androsta-1,4-dien-3,17-dion (A), the combined yield of fist two steps was 77 %. In the final step, exemestane was archived from compound 4 with 88.2 % yield. The synthesis achieved the overall yield of 67.9 %. The structures of exemestane and intermediate products were confirmed by MS and NMR.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/54661
ISSN: 0866-7861
Appears in Collections:Dược học

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