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Title: | Tinh chế, xác định hàm lượng và đánh giá độc tính cấp của tác nhân kháng khuẩn linezolid |
Authors: | Nguyễn, Quốc Vượng Trần, Thị Bích Vân Nguyễn, Thị Liên Vũ, Văn Chiến Phạm, Thị Hằng Nguyễn, Thị Huế |
Keywords: | Linezolid Purification HPLC Acute toxicity |
Issue Date: | 2018 |
Series/Report no.: | Tạp chí Dược học;Số 510 .- Tr.52-55 |
Abstract: | Linezolid was synthesized, purified, and evaluated for acute toxicity. The purity of the synthesized linezolid was analyzed by HPLC as follows: Column - Phenomenex Rp18(5 pm, 150 mm x 4.6 mm); Flow rate -1.0 ml/min; Detector- UV (251 nm): Mobile phase - Monobasic ammonium phosphate buffer (0.23 g/1000 mL)/Methanol 75/25 (v/v). By calibration curves, the purity of the obtained linezolid was found to attain 99.7%, with two impurities in quite low percentages (0.012% and 0.021%). /4s thus, synthesized linezolid showed well meet the requirments by USP 2012. Acute toxicity of the linezolid in mouse was performed at the dose level of 5000 - 8000 mg/kgP of mouse and observed for 7 consecutive days. The LD^value (6.32 ± 0.24) g/1 kg of mouse proved low toxicity of linezolid. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/54669 |
ISSN: | 0866-7861 |
Appears in Collections: | Dược học |
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