Nghiên cứu tổng hợp thuốc chống ung thư pazopanib hydroclorid. Phần II: Tổng hợp pazopanib hydroclorid từ 2,3-dimethyl-1H-indazol-6-amin ở quy mô phòng thí nghiệm

Abstract

Pazopanib hydrochloride, a tyrosine kinase inhibitor, was synthesized by combinating indazole 2 and 2,4-dichloropyrimidine and sulfonamide 3 inthe overall yield of 42.7%. The structure of the synthesized intermediates and final product were confirmed by IR, NMR and MS.