Phương pháp cải tiến tổng hợp bortezomib

Abstract

Viewing bortezomib as one of the first therapeuticals of antineoplastic drugs for patients with multiple myeloma and mantle lymphoma cells, the synthetic process of bortezomib was improved for simplicity better yield. The synthesized compounds were qulitatively confirmed by NMR and MS quantitatvely determined by HPLC. The synthesis achieved the yield of approximately 40%, the obtained bortezomib had the purity above 90%.