Nghiên cứu tổng hợp và thử hoạt tính kháng khuẩn một số dẫn chất Sulfonamid mới của benzimidazol

Abstract

Benzimidazole sulfonamides were synthesized by combination of two pharmacologically compatible moieties into a single molecule by attaching a sulfonamide moiety to a benzimidazole frame. Their structures are confirmed by 1H-NMR-spectroscopy and mass spectrometry. Of the 8 synthesized compounds, 7 (5a-7a, 4b-7b) were novel benzimidazole sulfonamides. The antibacterial activities of all the 8 synthesized compounds (4a-7a, 4b-7b) against standard strains of 5 Gram positive and 5 Gram negative bacteria were tested at 500 pg/mL by disk diffusion method. Of these, two sulfonamides (4a, 7b) showed promising antibacterial activity against both types of the tested bacteria.