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Title: | Nghiên cứu tổng hợp felodipin bằng phương pháp Hanzsch |
Authors: | Vũ, Minh Tân Lê, Thị Hồng Nhung Nguyễn, Ngọc Thanh Nguyễn, Quang Tùng Đoàn, Duy Tiên |
Keywords: | 2,3-Dichlorobenzaldehyde MBI Ethyl 3-aminocrotonate Methyl acetoacetate Felodipine |
Issue Date: | 2018 |
Series/Report no.: | Tạp chí Dược học;Số 510 .- Tr.75-77 |
Abstract: | Felodipine, as a medicine of the calcium channel blocker type for treatment of high blood pressure, was synthesized by reaction between methyl 2-(2,3-dichlorobenzylidene)acetoacetate with ethyl 3-aminocrotonate in tert-butanol under the catalytic pyridine at a temperature of 80°C for 8 hours and molar ratio was 1.0:1.3 to obtain the product in 89.6% yield. Note that for use as material of this synthesis, methyl 2-(2,3-dichlorobenzylidene)acetoacetate and ethyl 3-aminocrotonate was prepared by a propsed method. The structure of the obtained product was determined by IR, NMR and LC- MS. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/54680 |
ISSN: | 0866-7861 |
Appears in Collections: | Dược học |
Files in This Item:
File | Description | Size | Format | |
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_file_ Restricted Access | 2.22 MB | Adobe PDF | ||
Your IP: 3.145.12.233 |
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