Nghiên cứu tổng hợp felodipin bằng phương pháp Hanzsch

Abstract

Felodipine, as a medicine of the calcium channel blocker type for treatment of high blood pressure, was synthesized by reaction between methyl 2-(2,3-dichlorobenzylidene)acetoacetate with ethyl 3-aminocrotonate in tert-butanol under the catalytic pyridine at a temperature of 80°C for 8 hours and molar ratio was 1.0:1.3 to obtain the product in 89.6% yield. Note that for use as material of this synthesis, methyl 2-(2,3-dichlorobenzylidene)acetoacetate and ethyl 3-aminocrotonate was prepared by a propsed method. The structure of the obtained product was determined by IR, NMR and LC- MS.