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https://dspace.ctu.edu.vn/jspui/handle/123456789/54709
Title: | Nghiên cứu xây dựng và thẩm định phương pháp phân tích đồng thời methylparaben, epirubicin trong thuốc tiêm đông khô epirubicin 50 mg bằng sắc ký lỏng hiệu năng cao |
Authors: | Phan, Thị Mỹ Hoàng Võ, Thị Thu Hiền |
Keywords: | Epirubicin Methylparaben Validation |
Issue Date: | 2018 |
Series/Report no.: | Tạp chí Dược học;Số 511 .- Tr.86-88 |
Abstract: | An HPLC method for simultaneous quantitative analysis of epirubicin hydrochloride (C₂₇H₂₉NO₁₁ HCI) methyl paraben (C₈H₈O₃ in the injectable lyophilized mixture with lastose monohydrate was established as: Column -Trirnethylsilyl silica gel (25 cm x 4.6 mm, 5µm); Column temperature - 35°C; Detector - UV (254 nm); Mobile phase - a mixture of methanol - acetonitrile - solution of sodium dodecyl sulfate 0.37 % (w/v) in orthophosphoric acid 0.28 M (17: 29: 54); Isocratic mode of elution, Flow rate - 2.5 ml/min; The procedure was validated to confirm system compatibility, define the linearity range, detection limit (LOD), quantitation limit (LOQ), accuracy, precision and repeatability. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/54709 |
ISSN: | 0866-7861 |
Appears in Collections: | Dược học |
Files in This Item:
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_file_ Restricted Access | 2.36 MB | Adobe PDF | ||
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