Tối ưu hóa công thức bào chế tiểu phân nano dihydroartemisinin với chất mang Eudragit EPO

Abstract

Dihydroartemisinin-loaded Eudragit EPO-based nanoparticles were made by oil/water emulsion evaporation. Influence of several formulation factors on physicochemical characteristics of nanoparticles was evaluated to optimize the formulation. Experiments were designed by Modde 8.0 and analyzed by FormRuie 2.0 and InForm 3.1 to determine the impacts of three independent variables (ratio of dihydroartemisinin to Eudragit EPO, concentrations of Cremophor A25 and volume of aqueous phase) on some response variables (particle size, polydispersity index, zeta potential, loading capacity and encapsulation efficiency). The optimized formulation was obtained with size of 170 nm, PDI below 0.3, zeta potential of 23.1 mV, encapsulation efficiency of 42.3 % and loading capacity of 11.21 %.