Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/54712
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dc.contributor.authorTạ, Mạnh Hùng-
dc.contributor.authorĐoàn, Cao Sơn-
dc.contributor.authorLê, Thị Thu Huyền-
dc.contributor.authorTrần, Hoàng-
dc.contributor.authorPhan, Thị Nghĩa-
dc.contributor.authorHà, Thị Tuyển-
dc.date.accessioned2021-06-09T09:06:23Z-
dc.date.available2021-06-09T09:06:23Z-
dc.date.issued2018-
dc.identifier.issn0866-7861-
dc.identifier.urihttps://dspace.ctu.edu.vn/jspui/handle/123456789/54712-
dc.description.abstractThe pharmacokinetics and bioequivalence of the two preparations of Losartan 100 mg tablets were evaluated by a two-way cross-over randomized study. The study involved 24 Vietnamese healthy volunteers taking a single oral dose. Losartan and its main active metabolite in the human plasma samples collected at given intervals of time after administration (0-36h) were assayed by high performance liquid chromatography (HPLC) with positive turbo ion spray ionization tandem mass spectrometry detection (HPLC-MS). The observed pharmacokinetic parameters including area under the curve total (AUC) and to infinity (AUCmax), peak plasma concentration (Cmax), time to attain peak (Tmax), and elimination half-life (t1/2) were determined and analyzed statistically. Statistically, no significant differences were recored in Cmax and AUC of both losartan and its active metabolite. In the bioequivalence range of 0.8 - 1.25 confidence limits calculated for AUC and Cmax of losartan and its metabolitere were 90 % and 95 %, respectively. These finding confirmed the tested formulation to be well bioequivalent to the reference with respect to losartan and its main active metabolite.vi_VN
dc.language.isovivi_VN
dc.relation.ispartofseriesTạp chí Dược học;Số 512 .- Tr.10-13-
dc.subjectBioequivalencevi_VN
dc.subjectLosartanvi_VN
dc.subjectActive metabolitevi_VN
dc.subjectVietnamese volunteervi_VN
dc.titleNghiên cứu dược động học và đánh giá tương đương sinh học viên nén bao phim Losartan kali 100 mg sản xuất tại Việt Namvi_VN
dc.typeArticlevi_VN
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