Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/54715
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dc.contributor.authorNguyễn, Lâm Hồng-
dc.contributor.authorĐào, Tú Anh-
dc.contributor.authorLê, Công Vinh-
dc.contributor.authorPhạm, Văn Cường-
dc.contributor.authorĐoàn, Thị Mai Hương-
dc.contributor.authorTrần, Việt Hùng-
dc.date.accessioned2021-06-09T09:18:34Z-
dc.date.available2021-06-09T09:18:34Z-
dc.date.issued2018-
dc.identifier.issn0866-7861-
dc.identifier.urihttps://dspace.ctu.edu.vn/jspui/handle/123456789/54715-
dc.description.abstractOn continuance of the previous programmed screening to reveal that ethyl acetate extracts from the fruits of the 2 Cleistanthus species (C. indochinensls Merr. ex Croiz and C. tonkinensis Jab!., Euphorbiaceae) possessing a strong cytotoxicity against KB cells (88.4 and 95.2 % inhibition at 1 µg/mL), cleistantoxin and some aryltetralin lignans were isolated from these species. The obtained cleistantoxin was identified physically by appearance, melting range (199 - 202 °C), specific rotation ([α]D²⁰= -133,400), and spectrometrically by 1D-NMR, 2D-NMR, HR-MS, CD, IR, UV, etc. As the major active component of the plant, Cleistantoxin proved to have a significant cytotoxicity against the following cancer cell lines: MCF-7 (IC₅₀ = 0.036 µM), MCF-7R (ICX= 0.014 µM) and HT29 (IC₅₀= 0.035 µM). In addition, cleistantoxin showed structural similarity to etoposide which is currently used for lung cancer treatment. To establish a primary chemical reference substance (PCRS). 4.023 g cleistantoxin was purified (>99.0% by HPLC/DAD analysis), meeting the quality and purity requirments of the International Pharmacopoeia (IP) and World Health Organization (WHO) guide.vi_VN
dc.language.isovivi_VN
dc.relation.ispartofseriesTạp chí Dược học;Số 512 .- Tr.21-24-
dc.subjectCleistanthus tonkinensis Jablvi_VN
dc.subjectIsolationvi_VN
dc.subjectIdentificationvi_VN
dc.subjectPurity determinationvi_VN
dc.subjectCleistantoxinvi_VN
dc.titleNghiên cứu phân lập, nhận dạng cleistantoxin từ quả cây chà chôi (Cleistanthus tonkinensis Jabl., Euphorbiaceae) làm nguyên liệu thiết lập chất chuẩnvi_VN
dc.typeArticlevi_VN
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