Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/54720
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dc.contributor.authorNguyễn, Thị Thuận-
dc.contributor.authorNguyễn, Hải Nam-
dc.contributor.authorĐoàn, Thanh Hiếu-
dc.date.accessioned2021-06-09T09:29:32Z-
dc.date.available2021-06-09T09:29:32Z-
dc.date.issued2018-
dc.identifier.issn0866-7861-
dc.identifier.urihttps://dspace.ctu.edu.vn/jspui/handle/123456789/54720-
dc.description.abstractA series of 6 novel benzamid incorporating quinazoline heterocycles (4a-f) were synthesized as novel histone deacetylases Inhibitors. By bioevaluation, these quinazoline-based benzamide showed potent cytotoxicity against the following three human cancer cell lines: SW620 (colon), PC-3 (prostate) and NCI-H23 (lung), displaying the potency 5 - up to 10-fold higher than SAFIA (suberoylanilidehydroxamic acid, vorinostat). Also, these compounds were comparable to SAHA in inhibiting HDACs with IC₅₀ values within the sub-micromolar range. Of these, two compounds (4c) and (4f) were HDAC inhibitors even more potent than SAHA in Hela extract assay and expected to be promising anticancer drug candidates.vi_VN
dc.language.isovivi_VN
dc.relation.ispartofseriesTạp chí Dược học;Số 512 .- Tr.41-44-
dc.subjectHDACvi_VN
dc.subjectHiston deacetylasevi_VN
dc.subjectAcid hydroxamicvi_VN
dc.titleTổng hợp và thử hoạt tính sinh học của một số dẫn chất benzamid có nhân quinazolinvi_VN
dc.typeArticlevi_VN
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