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https://dspace.ctu.edu.vn/jspui/handle/123456789/54754
Title: | Tổng hợp một số dẫn chất 6-(n-butylamino)-2-arylquinazolin-4(3H)-on hướng kháng ung thư |
Authors: | Lê, Nguyễn Thành Trần, Minh Huệ Ngô, Xuân Hoàng Hoàng, Thu Trang Đinh, Ngọc Thức Văn, Thị Mỹ Huệ |
Keywords: | 6-Butylamino-2-arylquinazolin-4-on Cytotoxicity Cancer cell |
Issue Date: | 2018 |
Series/Report no.: | Tạp chí Dược học;Số 512 .- Tr.75-80 |
Abstract: | A senes of 2-arylquinazolin-4(3H)-on was designed in expectaion of anticancer effects. Substitutions at C6 and C2' position < >f ¡he structures were introduced. Targeted compound 6a-d were obtained by a 3-steps pathway from 2-amlno-5-butylannnobenzamid and corresponding aldehydes. Cytotoxicity of the synthesized compounds were tested against two cancer cell lines (human epidermic carcinoma-KB and hepatocellular carcinoma-HepG2). As expected, all the tested compounds exhibited stronger cytotoxicity than ellipticine. Notably, compound 6c and 6d exposed the desirable activity 18 -21 times as strong as ellipticine with IC50 ranging at 0,09-0,12 uM. These findings clarified why the 2-arylquinazolin-4(3H)-on derivatives with 2’-substitution have been considered as very potential anticancer agents. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/54754 |
ISSN: | 0866-7861 |
Appears in Collections: | Dược học |
Files in This Item:
File | Description | Size | Format | |
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_file_ Restricted Access | 3.91 MB | Adobe PDF | ||
Your IP: 18.191.171.43 |
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