Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/54754
Title: Tổng hợp một số dẫn chất 6-(n-butylamino)-2-arylquinazolin-4(3H)-on hướng kháng ung thư
Authors: Lê, Nguyễn Thành
Trần, Minh Huệ
Ngô, Xuân Hoàng
Hoàng, Thu Trang
Đinh, Ngọc Thức
Văn, Thị Mỹ Huệ
Keywords: 6-Butylamino-2-arylquinazolin-4-on
Cytotoxicity
Cancer cell
Issue Date: 2018
Series/Report no.: Tạp chí Dược học;Số 512 .- Tr.75-80
Abstract: A senes of 2-arylquinazolin-4(3H)-on was designed in expectaion of anticancer effects. Substitutions at C6 and C2' position < >f ¡he structures were introduced. Targeted compound 6a-d were obtained by a 3-steps pathway from 2-amlno-5-butylannnobenzamid and corresponding aldehydes. Cytotoxicity of the synthesized compounds were tested against two cancer cell lines (human epidermic carcinoma-KB and hepatocellular carcinoma-HepG2). As expected, all the tested compounds exhibited stronger cytotoxicity than ellipticine. Notably, compound 6c and 6d exposed the desirable activity 18 -21 times as strong as ellipticine with IC50 ranging at 0,09-0,12 uM. These findings clarified why the 2-arylquinazolin-4(3H)-on derivatives with 2’-substitution have been considered as very potential anticancer agents.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/54754
ISSN: 0866-7861
Appears in Collections:Dược học

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