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DC Field | Value | Language |
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dc.contributor.author | Lê, Nguyễn Thành | - |
dc.contributor.author | Trần, Minh Huệ | - |
dc.contributor.author | Ngô, Xuân Hoàng | - |
dc.contributor.author | Hoàng, Thu Trang | - |
dc.contributor.author | Đinh, Ngọc Thức | - |
dc.contributor.author | Văn, Thị Mỹ Huệ | - |
dc.date.accessioned | 2021-06-11T01:19:33Z | - |
dc.date.available | 2021-06-11T01:19:33Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0866-7861 | - |
dc.identifier.uri | https://dspace.ctu.edu.vn/jspui/handle/123456789/54754 | - |
dc.description.abstract | A senes of 2-arylquinazolin-4(3H)-on was designed in expectaion of anticancer effects. Substitutions at C6 and C2' position < >f ¡he structures were introduced. Targeted compound 6a-d were obtained by a 3-steps pathway from 2-amlno-5-butylannnobenzamid and corresponding aldehydes. Cytotoxicity of the synthesized compounds were tested against two cancer cell lines (human epidermic carcinoma-KB and hepatocellular carcinoma-HepG2). As expected, all the tested compounds exhibited stronger cytotoxicity than ellipticine. Notably, compound 6c and 6d exposed the desirable activity 18 -21 times as strong as ellipticine with IC50 ranging at 0,09-0,12 uM. These findings clarified why the 2-arylquinazolin-4(3H)-on derivatives with 2’-substitution have been considered as very potential anticancer agents. | vi_VN |
dc.language.iso | vi | vi_VN |
dc.relation.ispartofseries | Tạp chí Dược học;Số 512 .- Tr.75-80 | - |
dc.subject | 6-Butylamino-2-arylquinazolin-4-on | vi_VN |
dc.subject | Cytotoxicity | vi_VN |
dc.subject | Cancer cell | vi_VN |
dc.title | Tổng hợp một số dẫn chất 6-(n-butylamino)-2-arylquinazolin-4(3H)-on hướng kháng ung thư | vi_VN |
dc.type | Article | vi_VN |
Appears in Collections: | Dược học |
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_file_ Restricted Access | 3.91 MB | Adobe PDF | ||
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