Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/54754
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dc.contributor.authorLê, Nguyễn Thành-
dc.contributor.authorTrần, Minh Huệ-
dc.contributor.authorNgô, Xuân Hoàng-
dc.contributor.authorHoàng, Thu Trang-
dc.contributor.authorĐinh, Ngọc Thức-
dc.contributor.authorVăn, Thị Mỹ Huệ-
dc.date.accessioned2021-06-11T01:19:33Z-
dc.date.available2021-06-11T01:19:33Z-
dc.date.issued2018-
dc.identifier.issn0866-7861-
dc.identifier.urihttps://dspace.ctu.edu.vn/jspui/handle/123456789/54754-
dc.description.abstractA senes of 2-arylquinazolin-4(3H)-on was designed in expectaion of anticancer effects. Substitutions at C6 and C2' position < >f ¡he structures were introduced. Targeted compound 6a-d were obtained by a 3-steps pathway from 2-amlno-5-butylannnobenzamid and corresponding aldehydes. Cytotoxicity of the synthesized compounds were tested against two cancer cell lines (human epidermic carcinoma-KB and hepatocellular carcinoma-HepG2). As expected, all the tested compounds exhibited stronger cytotoxicity than ellipticine. Notably, compound 6c and 6d exposed the desirable activity 18 -21 times as strong as ellipticine with IC50 ranging at 0,09-0,12 uM. These findings clarified why the 2-arylquinazolin-4(3H)-on derivatives with 2’-substitution have been considered as very potential anticancer agents.vi_VN
dc.language.isovivi_VN
dc.relation.ispartofseriesTạp chí Dược học;Số 512 .- Tr.75-80-
dc.subject6-Butylamino-2-arylquinazolin-4-onvi_VN
dc.subjectCytotoxicityvi_VN
dc.subjectCancer cellvi_VN
dc.titleTổng hợp một số dẫn chất 6-(n-butylamino)-2-arylquinazolin-4(3H)-on hướng kháng ung thưvi_VN
dc.typeArticlevi_VN
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