Isoflavones from Placolobium Vietnamense, an indigenous plant of Vietnam

Abstract

Placolobium Vietnamense N.D.Khoi & Yakovlev (Fabaceae) is an indigenous plant of Vietnam. Up to now, this plant has not yet been chemically and biologically studied. In this paper, six isoflavones including afrormosin (1), cladrastin (2), 8-D-methylretusin (3), millesianin C (4), barbigerone (5), and durallone (6) were isolated from the ethyl acetate extract of the stem bark of Placolobium Vietnamense. Their structures were established by means of physical data (ESI MS, 1D and 2D NMR) and evaluated for the cytotoxic activities against liver hepatocellular carcinoma (HepG2), human lung cancer (NCI-H460), human epithelial carcinoma (Hel.a) and human breast cancer (MCF-7) cell lines. This is the first report on phytochcmical studies of this plant.