New iridoid from Valeriana hardwickii Wall

Abstract

A new iridoid, (4S,5R,6S,7S,9S)-7,10,11-trihydroxy dihydronepetalactone (1) together with four known flavonoids including linarin, neodiosmin, neobudofficide and rhoifolin were isolated from aerial parts of Valeriana hardwickii Wall.. Chemical structures were elucidated by extensive spectroscopic analyses including ESI-HRMS and 1D, 2D-NMR spectral data as well as by comparison with those reported in the literatures. Compound 1 showed no cytotoxic activity toward three human cancer cell lines (CCRF-CEM, MDA-MB-231 and HCT-116).