Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/61237
Title: Isolation of lignans and neollgnans from Pouzolzia sanguinea with their cytotoxic activity
Authors: Le, Thi Hong Nhung
Nguyen, Thi Hoang Anh
Bui, Huu Tai
Phan, Van Kiem
Keywords: Pouzolzia sanguinea
Lignan
Neolignan
Cytotoxicity
Issue Date: 2021
Series/Report no.: Vietnam Journal of Chemistry;No 59(2) .- P.146-152
Abstract: One lignan (7'S’,8'R,8S)-4,4'-dihydroxy-3,3',5,5'-tetramethoxy-7',9-epoxylignan-9'-ol-7-one (1) together with four neolignans (7α,8α)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside (2), (7α,8α)-dihydrodehydro-diconiferyl alcohol 9'-O-β-D-glucopyranoside (3). icariside E₃ (4). and icariside E₅ (5) were isolated from Pouzohia sanguinea. Their chemical structures were elucidated by ESI-MS, NMR spectra, as well as in comparison with the data reported in literature. At concentration of 30 µM, compounds 1-5 exhibited weak cytotoxic activity with cell viability percentages ranging from 59.9±0.98 % to 84.2±0.98 % and from 77.7±0.81 % to 100.3±0.78 % on CAL27 (oral adenosquamous carcinoma cell) and MDA-MB-321 (breast cancer cell) cell lines, respectively.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/61237
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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