Lignans from the stems of Clerodendrum inerme Gaertn

Abstract

The polar constituents of Clerodendrum inerme collected from coastal area of Thai Binh province were investigated. From the water soluble fraction of the C. inerme stems, four lignan and lignan glucosides ( 1-4) along with a phenolic glucoside (5) were isolated. Their chemical structures were established as icariol A₂ (1), syringaresinol-4-O- β-Tglucopyranoside (2), lariciresinol-4-O-β-D-glucopyranoside (3), dehydrodiconiferyl alcohol-4-O-β-D- glucopyranoside (4) and leonurisidc A (5) by NMR spectroscopic and mass spectrometric analysis as well as comparison with those reported in the literature. Compounds 1, 2, 3 and 5 were found for the first time from this plant.