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Title: | Synthesis, characterization and anticancer properties of platinum(ll) complexes bearing chiral azomethine ligands |
Authors: | Nguyen, Quang Trung Pham, Thi Phuong Nam Nguyen, Van Tuyen |
Keywords: | Chiral azomethine ligand Pt(II) complexes Characterization Photophysical properties Anticancer activity |
Issue Date: | 2021 |
Series/Report no.: | Vietnam Journay of Chemistry;No.59(2) .- P.221-228 |
Abstract: | Pt(ll) complexes bearing one ,N-salicylidene-(S)-l-phenylethylamine [HL(S)] or N-salicylidene-(R)-1- phenylethylamine [HL(R)] were synthesized and characterized by electrospray ionization mass spectroscopy (ESI-MS), Fourier-transform infrared (FT-IR), nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopies. The results of the micro-analytic and spectroscopic methods disclosed that the reaction of K₂PtCI₄ with the chiral azomethine ligand in DMSO produced both trails- and cis-[Pt(Il)L(DMSO)CI], Then only trans-[Pt(ll)L(DMSO)Cl] isomers in Na₂CO₃ solution can transform to Pt(Il) complexes 3 in coordination of the ligands to platinum as tridentate C,N,O-donors. The photophysical properties of obtained platinum(II) complexes were studied by UV-visible and luminescent spectra. The results showed that they all exhibited emission in the visible region. Anticancer properties in vitro of obtained Pt(ll) complexes were scaned for KB and HepG-2 cancer cell lines. They had good activity for the tested cancer cells. The cis-Pt(II) complexes possessed higher anticancer activity than trans-Pt(II) complexes and R- cnantiomers were found to be more cytotoxic than S-enantiomers. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/61284 |
ISSN: | 2525-2321 |
Appears in Collections: | Vietnam Journal of Chemistry |
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