Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/66727
Title: Synthesis of two new hydroximinosteroids from cholesterol and their biological evaluation
Authors: Dinh, Thi Ha
Salvaraja, Baskar
Pham, Quoc Long
Ngo, Dai Quang
Do, Huu Nghi
Jae Wook, Lee
Tran, Thi Thu Thuy
Keywords: Cholesterol
Hydroximinosteroid
HeLa
HepG2
T98G
Issue Date: 2019
Series/Report no.: Vietnam Journal of Science and Technology;Vol. 57, No. 05 .- P.527–538
Abstract: A simple and efficient synthesis of two new hydroximinosteroidal derivatives (11, 13) from cholesterol as starting material was described. The cytotoxicity of these compounds, their intermediates and two other known hydroximinosteroids were evaluated on human cancer cell lines including hepatocellular carcinoma (Hep-G2), cervical cancer (HeLa) and glioblastoma (T98G). Compound 13 presented a potent antiproliferative effect to T98G cancer cell at 2.9 µM of IC₅₀. Our results demonstrated that the compound with oxime group at C-6 having better cytotoxic activity against tested cell lines. Presence of 4,5–double bond or 4,5–epoxide can increase cytotoxicity for the 3,6–dihydroximino derivatives. In addition, the antimicrobial assay showed that two new oximes 11 and 13 were active against E. coli and S. aureus strain (MIC value of 50 µg/mL). The active compounds may provide us a clue for a lead structure of anticancer and antimicrobial agents.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/66727
ISSN: 2525-2518
Appears in Collections:Vietnam journal of science and technology

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