Scaffold from micro electrospun polylactide acid and wet chemical hydrothermal reaction hydroxy apatite used for biomedical application

Abstract

Polylactic acid (PLA) microfibrous compositescaffolds having hydroxy apatite (HA) particlesin the fibers were prepared by electrospinning of PLA andwet chemical hydrothermal reaction HA with average diameter of 8.13 μm. The fibers were compressed in mould into bulk scaffolds. Microscopy characterizations confirmed integration of the crystalline HA and PLA fibers in both before and after compression. The morphology, porosity of scaffolds were examined by scanning electron microscope (SEM). The HA content were observed by SEM and determined by Thermogravimetry Analysis (TGA). Agglomeration gradually appeared and increased on the fiber surface along with the increase of HA concentration. The fiber diameter also increased with the HA concentration. Mechanical property of scaffold was examined by compressional strength test. The scaffold preparefor bone substitute implant application with suitable mechanical performance and morphology.