Screening of the matrix metalloproteinase inhibitory activity on extracts from Cordyceps rteovolkiana 1)1,0004 and Cordyceps takaomontana DL0038A fungi

Abstract

Matrix metalloproteinases (MMPs) are endopeptidases, they arc involved in tumor growth, and the processes of invasion and metastasis. Cordyceps spp. were recorded to have the anticancer potential. In previous studies, extracts from Cordyceps neovotkiana strain DI.0004 and Cordyceps takaomontana strain DL0038A were capable of cytotoxic activity against MCF-7 and Jurkat cell lines. In this study. 26 extracts were prepared from biomasses and fruit bodies of c. neovolkiana DL0004 and c takaomontana DL0038A, then proceed to screen for MMP inhibition assay bv concentration ranges of 2000 |ig/mL, 200 pg/mL, 20 pg/mL. The results showed that the CPS extract of the fruit body of the c. neovoikiana DL0004 had the highest activity in MMP inhibition with 84.27 fc 4.59% at 2000 pg/mL. The results were achievement for further studies of metastatic inhibition activities of Cordyceps extracts.