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Title: | New quinazolinone derivatives: Synthesis and in vitro cytotoxic activity |
Authors: | Tran, Dang Thinh Le, Thi Thuy Ta, Hong Duc Tran, Khac Vu |
Keywords: | 6-Hydroxy-4(3H) quinazolinone Cytotoxic Cancer |
Issue Date: | 2020 |
Series/Report no.: | Vietnam Journal of Science and Technology;Vol. 58, No. 01 .- P.12-20 |
Abstract: | The paper presents a simple synthesis of a series of new quinazolinone derivatives 13a-i. First, the reaction of 5-hydroxyanthranilic acid (11) with acetic anhydride at 160–180oC for 2 h gave the intermediate 12 in high yield. This intermediate was then reacted with amines in acetic acid at 180 °C for 14 h to afford new quinazolinone derivatives 13a-i in 69–92%. Synthesized compounds were structurally confirmed using spectroscopic methods: 1H, 13CNMR and MS spectra. The bioassay result using three cancer cell lines including SKLU-1 (lung cancer), MCF-7 (breast cancer) and HepG-2 (liver cancer) showed that only compound 13e exhibited significant cytotoxic effect against cancer cell lines tested with IC₅₀ values of 9.48, 20.39 and 18.04 µg/ mL, respectively. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/70898 |
ISSN: | 2525-2518 |
Appears in Collections: | Vietnam journal of science and technology |
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