Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/71136
Title: Palmitic acid activates NLRP3 inflammasome and induces placental inflammation during pregnancy in mice
Authors: Sano, Michiya
Shimazaki, Sayaka
Kaneko, Yasuaki
Karasawa, Tadayoshi
Takahashi, Masafumi
Ohkuchi, Akihide
Takahashi, Hironori
Kurosawa, Akira
Torii, Yasushi
Iwata, Hisataka
Kuwayama, Takehito
Shirasuna, Koumei
Keywords: Inflammation
NLRP3
Inflammasome
Placenta
Pregnancy
Issue Date: 2020
Series/Report no.: Journal of reproduction and development;Vol. 66, No. 03 .- P.241-248
Abstract: Maternal obesity is one of the major risk factors for pregnancy complications and is associated with low-grade chronic systemic inflammation due to higher levels of pro-inflammatory cytokines such as interleukin (IL)-1β. Pregnant women with obesity have abnormal lipid profiles, characterized by higher levels of free fatty acids, especially palmitic acid (PA). Previously, we reported that PA stimulated IL-1β secretion via activation of NLRP3 inflammasome in human placental cells. These observations led us to hypothesize that higher levels of PA induce NLRP3 inflammasome activation and placental inflammation, resulting in pregnancy complications. However, the effects of PA on NLRP3 inflammasome during pregnancy in vivo remain unclear.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/71136
ISSN: 0916-8818
Appears in Collections:The journal of reproduction and development

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