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https://dspace.ctu.edu.vn/jspui/handle/123456789/71156| Title: | Gpr120 mRNA expression in gonadotropes in the mouse pituitary gland is regulated by free fatty acids |
| Authors: | Deura, Chikaya Kimura, Yusuke Nonoyama, Takumi Moriyama, Ryutaro |
| Keywords: | Diurnal variation Fatty acid Gonadotrope GPR 120 Pituitary |
| Issue Date: | 2020 |
| Series/Report no.: | Journal of reproduction and development;Vol. 66, No. 03 .- P.249-254 |
| Abstract: | GPR120 is a long-chain fatty acid (LCFA) receptor that is specifically expressed in gonadotropes in the anterior pituitary gland in mice. The aim of this study was to investigate whether GPR120 is activated by free fatty acids in the pituitary of mice and mouse immortalized gonadotrope LβT2 cells. First, the effects of palmitate on GPR120, gonadotropic hormone b-subunits, and GnRH-receptor expression in gonadotropes were investigated in vitro. We observed palmitate-induced an increase in Gpr120 mRNA expression and a decrease in follicle-stimulating hormone b-subunit (Fshb) expression in LβT2 cells. |
| URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/71156 |
| ISSN: | 0916-8818 |
| Appears in Collections: | The journal of reproduction and development |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| _file_ Restricted Access | 2.04 MB | Adobe PDF | ||
| Your IP: 3.149.214.28 |
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