Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/71156
Title: Gpr120 mRNA expression in gonadotropes in the mouse pituitary gland is regulated by free fatty acids
Authors: Deura, Chikaya
Kimura, Yusuke
Nonoyama, Takumi
Moriyama, Ryutaro
Keywords: Diurnal variation
Fatty acid
Gonadotrope
GPR 120
Pituitary
Issue Date: 2020
Series/Report no.: Journal of reproduction and development;Vol. 66, No. 03 .- P.249-254
Abstract: GPR120 is a long-chain fatty acid (LCFA) receptor that is specifically expressed in gonadotropes in the anterior pituitary gland in mice. The aim of this study was to investigate whether GPR120 is activated by free fatty acids in the pituitary of mice and mouse immortalized gonadotrope LβT2 cells. First, the effects of palmitate on GPR120, gonadotropic hormone b-subunits, and GnRH-receptor expression in gonadotropes were investigated in vitro. We observed palmitate-induced an increase in Gpr120 mRNA expression and a decrease in follicle-stimulating hormone b-subunit (Fshb) expression in LβT2 cells.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/71156
ISSN: 0916-8818
Appears in Collections:The journal of reproduction and development

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