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https://dspace.ctu.edu.vn/jspui/handle/123456789/71727
Title: | Synthesis of sulfonylurea derivatives and their α-glucosidase inhibitory activity |
Authors: | Bui, Thi Thoi Ngo, Dai Quang Tran, Van Loc |
Keywords: | 6-chloronicotinic acid Sulfonyl carbamate Sulfonylurea derivatives |
Issue Date: | 2020 |
Series/Report no.: | Vietnam Journal of Science, Technology and Engineering;Vol. 62, No. 02 .- P.34-37 |
Abstract: | The paper describes the preparation of new sulfonylurea derivatives from sulfonyl carbamate 6 with amino derivatives. The process for synthesis of the key compound 6 included three steps starting from compound 6-chloronicotinic acid 1, which are readily available chemicals. The compound 1 in the presence of triethylaminc in anhydrous acetone solvent and ethyl chloroformate to obtain 6-chloronicotinic (ethyl carbonic) anhydride compound 3. The compound 3 were subsequently reacted with compound 4 to obtain compounds 5. The sulfonamides 5 was refluxed with ethyl chloroformate in present anhydrous potassium carbonate in dry acetone to obtain the key compounds 6. The total yield of the key intermediate compound 6 is about 81.35%, related to the starting materials. Finally, three sulfonylurea derivatives 7a-c were synthesized by condensation of 6 with various of amines in toluene. Their structures have been determined by IR, MS and 'H and ¹³C NMR spectroscopic methods, and their α-glucosidase inhibitory activity have been evaluated. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/71727 |
ISSN: | 2525-2461 |
Appears in Collections: | Vietnam journal of Science, Technology and Engineering |
Files in This Item:
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