Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/71734
Title: Angiotensin-converting enzyme inhibitory activity of some Vietnamese medicinal plants
Authors: Le, Xoan Thi
Phi, Xuyen Thi
Nguyen, Duong Thi Thuy
Pham, Hang Thi Nguyet
Nguyen, Van Tai
O, Olapoju Samuel
Matsumoto, Kinzo
Keywords: Angiotensin 1-converting enzy me
Antihypertensive
Leea rubra
Uncaria sessilifructus
Issue Date: 2020
Series/Report no.: Vietnam Journal of Science, Technology and Engineering;Vol. 62, No. 02 .- P.77-82
Abstract: This study investigated the angiotensin 1-converting enzyme (ACE) inhibitory activity of certain medicinal plants that have been traditionally used as an anti-hypertensive, diuretic, or related diseases treatment in Vietnam. Ten different medicinal plants were selected and screened for in vitro ACE inhibitory activity. A spectrophotometric assay was developed for the determination of ACE activity in the presence of ACE inhibitors using hippuryl-L-histidvl-L-leucine as the ACE-specific substrate. When the in vitro activities of ACE were assessed in the presence and absence of aqueous or ethanol extracts from each medicinal plant, 2 out of the 22 medicinal plant extracts inhibited the ACE activity by more than 90% at a concentration of 50 µg/ml. The estimated IC₅₀ value of the L. rubra and U. sessilifructus were 1.31±0.44 and 12.86 µg/ml, respectively. These results suggest that the L. rubra rhizome and U. sessilifructus extract are potential antihypertensive drug-like candidates with ACE inhibitory activity.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/71734
ISSN: 2525-2461
Appears in Collections:Vietnam journal of Science, Technology and Engineering

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