Study on cancer stem cell labeling and inhibition efficiency of LV3 nanocomplex in vitro

Abstract

Cancer stem cells (CSCs) are the cancer cells that have abilities to self-renew, differentiate into defined progenies, and to initiate and maintain tumour growth. They also contribute to cancer metastasis and therapeutic resistance, both of which are the principal causes of cancer mortality. Therefore, finding efficient fluorescent materials for CSC labelling and basic research is an urgent need. Thus, this research is focused on using a rare-earth element, which is the fluorescent Tb³⁺ nano-ion, and the CD133 monoclonal antibody to create a CSC-targeting nanocomplex (LV3).