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https://dspace.ctu.edu.vn/jspui/handle/123456789/81698
Title: | Modeling amino acid substitutions for whole genomes |
Authors: | Le, Sy Vinh |
Keywords: | Evolutionary analysis Amino acid substitution models Protein analysis Genome analysis Maximum likelihood estimation |
Issue Date: | 2021 |
Series/Report no.: | Journal of Computer Science and Cybernetics;Vol.37, No.04 .- P.351–363 |
Abstract: | Modeling amino acid substitution process is a core task in bioinformatics. New advanced sequencing technologies have generated huge datasets including whole genomes from various species. Estimating amino acid substitution models from whole genome datasets provides us unprecedented opportunities to accurately investigate relationships among species. In this paper, we review state-of-the-art computational methods to estimate amino acid substitution models from large datasets. We also describe a comprehensive pipeline to practically estimate amino acid models from whole genome datasets. Finally, we apply amino acid substitution models to build phylogenomic trees from bird and plant genome datasets. We compare our newly reconstructed phylogenomic trees and published ones and discuss new findings. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/81698 |
ISSN: | 1813-9663 |
Appears in Collections: | Tin học và Điều khiển học (Journal of Computer Science and Cybernetics) |
Files in This Item:
File | Description | Size | Format | |
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_file_ Restricted Access | 2.69 MB | Adobe PDF | ||
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