Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/85401
Title: Detection of single nucleotide polymorphisms (SNPs) in a SARS-CoV-2 virus strain in Vietnam
Authors: Tran, Xuan Thach
Bui, Thi Thuy Duong
Le, Van Truong
Nguyen, Thi Hoa
Pham, Thi Lanh
Nguyen, Thai Uy
Le, Quynh Mai
Dang, Duc Anh
Dinh, Duy Khang
Dong, Van Quyen
Keywords: Covid-19
Human coronaviruses
SARS-CoV-2
SNPs
Vietnam
Issue Date: 2021
Series/Report no.: Academia journal of biology;Vol.43, No.02 .- P. 95-105
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of a pandemic of acute respiratory disease in humans. This pandemic has now spread worldwide and caused more than 2,000,000 deaths by 15 January 2021. The complexity and the ongoing pandemic of coronavirus SARS-CoV-2 make it difficult to control the disease. Sequence analysis on some open reading frames (ORFs) of a SARS-CoV-2 virus strain isolated in Vietnam in February 2020 (SARS-CoV-2/NIHE/human/2020/VIE strain) revealed some single nucleotide polymorphisms (SNPs) that only appeared in the Vietnamese strain in comparison to those of the isolates in other countries, including: (1) a change in ORF8-Nucleocapsid (accession number MT127114.1) at nucleotide (nt) 691 (CTC in SARS-CoV-2/NIHE/human/2020/VIE strain, TTC in all other isolates) but it does not change the encoded amino acid, (2) ORF3a-EM-ORF6-ORF7a region (accession number MT127115.1) has four-point changes, three of which lead to changes in the amino acid sequences, being nt 479 (GTA encoding Valine changed into TTA encoding Leucine), nt 575 (CGC encoding Arginine changed to GGC encoding Glycine) in the M gene, and nt 1126 (GTG encoding Valine changed to GAG encoding Glutamic acid) in ORF6. Taken together, the results provided useful information for the SARS-CoV-2 diagnostic kit and vaccine development.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/85401
ISSN: 2615-9023
Appears in Collections:Academia journal of biology

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