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Title: Withanolides from the whole plant of Physalis angulata and their anti-inflammatory activities
Authors: Pham, Hai Yen
Le, Canh Viet Cuong
Ton, That Huu Dat
Dinh, Thi Quy Thuy
Dang, Thi Ngoc Hoa
Nguyen, Thi Cuc
Duong, Thi Hai Yen
Do, Thi Thao
Hoang, Le Tuan Anh
Keywords: Physalis angulata
Anti-inflammatory activity
Physagulin L
Physagulin M
Issue Date: 2019
Series/Report no.: Vietnam Journal of Chemistry;No 57(03) .- Page.334-338
Abstract: From the dichloromethane extract of the whole plant of P. angulata growing in Vietnam, three withanoIides including physagulin L (1), physagulin M (2), and withaminimin (3) were isolated by using various chromatography methods. Their chemical structures were determined by detailed analysis of 1D and 2D-NMR data and comparison with reported data. All isolated compounds were tested for their inhibitory activities against NO production in LPS-stimulated RAW 264.7 macrophages. The results showed that compound 3 had a weak anti-inflammatory activity against NO production in RAW 264.7 macrophages with IC₅₀ value of 69.6±4.5 µM.
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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