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https://dspace.ctu.edu.vn/jspui/handle/123456789/22198| Title: | Synthesis of Valsartan as drug for the treatment of hypertension |
| Authors: | Tran, Van Chien Nguyen, The Anh Tran, Thi Phuong Thao Le, Dac Phuong Pham, Thi Tham Nguyen, Quang Tung Tran, Van Loc |
| Keywords: | Valsartan Antihypertension Biphenyltetrazole Lewis acid |
| Issue Date: | 2019 |
| Series/Report no.: | Vietnam Journal of Chemistry;No 57(03) .- Page.343-346 |
| Abstract: | The synthesis of valsartan (1), one of the most currently used pharmaceutical agent in antihypertensive therapy, was described through five steps in an overall yield of 54 % starting from 4’-methyl-2-cyanobiphenyl (2). The key step involved tetrazole ring formation catalyzed by Lewis acid. The structures of synthesized compounds were confirmed by means of NMR and MS spectroscopie. |
| URI: | http://dspace.ctu.edu.vn/jspui/handle/123456789/22198 |
| ISSN: | 2525-2321 |
| Appears in Collections: | Vietnam Journal of Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| _file_ Restricted Access | 2.01 MB | Adobe PDF | ||
| Your IP: 18.223.32.230 |
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