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Title: Synthesis of Valsartan as drug for the treatment of hypertension
Authors: Tran, Van Chien
Nguyen, The Anh
Tran, Thi Phuong Thao
Le, Dac Phuong
Pham, Thi Tham
Nguyen, Quang Tung
Tran, Van Loc
Keywords: Valsartan
Lewis acid
Issue Date: 2019
Series/Report no.: Vietnam Journal of Chemistry;No 57(03) .- Page.343-346
Abstract: The synthesis of valsartan (1), one of the most currently used pharmaceutical agent in antihypertensive therapy, was described through five steps in an overall yield of 54 % starting from 4’-methyl-2-cyanobiphenyl (2). The key step involved tetrazole ring formation catalyzed by Lewis acid. The structures of synthesized compounds were confirmed by means of NMR and MS spectroscopie.
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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