Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/23314
Title: Protein tyrosine phosphatase 1B inhibitory activities of compounds isolated from Polygonum cuspidatum
Authors: Le, Hong Luyen
Pham, Minh Quan
Nguyen, Phi Hung
Keywords: Polygonaceae
Polygonum
Polygonum cuspidatum
PTP1B
Antidiabetes
Issue Date: 2019
Series/Report no.: Vietnam Journal of Chemistry;No 57(04) .- Page.496-499
Abstract: In the search for new natural PTP1B inhibitory compounds from medicinal plants, two 9,10-anthraquinones were isolated and structurally identitfed as physcion (1) and emodin (2) from the alcoholic extract of the root of Polygonum cuspidatum. Chemical structures of these isolates were identified by interpretation of spectroscopic data (¹H, ¹³C NMR and MS) as well as comparing with reported literatures. Compounds 1-2 possessed inhibitory activity on PTP1B enzyme with IC₅₀ values of 26.1 ± 0.7 and 13.3 ± 0.4 µM, respectively. Ursolic acid was used as positive control showing an IC₅₀ value of 3.5 ± 0.2 µM in this assay. This result reveals that these 9,10-anthraquinones might be considered as new natural compounds for development of antidiabetic agents.
URI: http://dspace.ctu.edu.vn/jspui/handle/123456789/23314
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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