Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/25479
Title: Polyoxygenated polyketides from the marine-derived fungus Aspergillus micronesiensis
Authors: Nguyen, Dinh Luyen
Le, Mai Huong
Tran, Thi Hong Ha
Le, Huu Cuong
Duong, Thi Hai Yen
Bui, Huu Tai
Nguyen, Xuan Nhiem
Phan, Van Kien
Keywords: Aspergillus micronesiensis
Polyketide
Epicoccolide A
Epicoccolide B
Epicoccone B
Issue Date: 2019
Series/Report no.: Vietnam Journal of Chemistry;Số 57(05) .- Tr.654-660
Abstract: Using combined chromatographic methods, seven compounds as epicoccolide A (1), epicoccolide B (2), 2-0-methylbutyrolactone II (3), NC3B (4), epicoccone B (5), (22E,24R)-5α.8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (6), and 4-hydroxybenzaldehyde (7) were isolated from the marine-derived fungus Aspergillus micronesiensis. Their chemical structures were determined by extensive analysis of HR-ESI-MS and NMR spectroscopy and comparison with those reported in the literature. All these compounds were isolated from Aspergillus micronesiensis for the first time. The seven compounds were assayed for their cytotoxic activity included Hep-02, LU-1 and Vero cells. compounds 1, 2, and 4 showed meaningful cytotoxic activity with the IC₅₀ values ranging from 3.97 to 4.71 µg/mL against three tested cell lines comparing to the ICM> values ranging from 0.29 to 0.31 µg/mL of the positive control compound ellipticine.
URI: http://dspace.ctu.edu.vn/jspui/handle/123456789/25479
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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