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Title: Facile Synthesis of 4-Oxo-4H-Quinolizine-2-carboxamide Derivatives
Authors: Bùi, Thị Bửu Huê
Võ, Đức Duy
Trương, Văn Kiệt
Tú, Thị Kim Cúc
Châu, Nguyên Trâm Yên
Mai, Văn Hiếu
Keywords: 4-oxo-4H-quinolizine
Stobbe condensation
Issue Date: 2015
Series/Report no.: Synthetic Communications;10.1080/00397911.2015.1112918
Abstract: A facile synthetic method for the construction of 2-substituted-4-oxo-4H-quinolizine-based core structure has been successfully developed. The synthesis made use of a one-pot Stobbe condensation followed by cyclization starting from the commercially available 2-pyridinecarbaldehyde. The structure of the formed 4-oxo-4H-quinolizine-2-carboxylate was fully confirmed by mass spectra, 1H NMR and 13C NMR, correlation spectrography, heteronuclear multiple bond correlation, and heteronuclear single quantum coherence (HSQC) spectra. The ethyl carboxylate moiety was then further functionalized via direct aminolysis by a range of amines to afford the corresponding 4-oxo-4H-quinolizine-2-carboxamides 4a–i in moderate to good yields.
ISSN: 0039-7911
Appears in Collections:Tạp chí quốc tế

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